ParkinsonCanadaV1, Main, Exploration, bibRecord, 001E50

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

Identifieur interne : 001E50 ( Main/Exploration ); précédent : 001E49; suivant : 001E51

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

Auteurs : Francesca Cicchetti [Canada] ; Janelle Drouin-Ouellet ; Robert E. Gross

Source :

Trends in pharmacological sciences [ 1873-3735 ] ; 2009.

RBID : pubmed:19729209

English descriptors

KwdEn :
- Animals, Disease Models, Animal, Environmental Exposure (adverse effects), Humans, Maneb (toxicity), Paraquat (toxicity), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (physiopathology), Pesticides (toxicity), Rotenone (toxicity).
MESH :
- chemical , toxicity : Maneb, Paraquat, Pesticides, Rotenone.
- adverse effects : Environmental Exposure.
- chemically induced : Parkinson Disease, Secondary.
- physiopathology : Parkinson Disease, Secondary.
- Animals, Disease Models, Animal, Humans.

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder largely of idiopathic nature with the exceptions of rare familial forms, and is characterized by both motor and non-motor disturbances. Pathologically, most motor features are the result of a dramatic loss of ventral tier mesencephalic dopaminergic neurons and thus dopamine content at their target sites. Although the exact etiology of the disease remains to be elucidated, it is thought to be multifactorial, with a critical role for environmental factors, such as pesticides, that may act on genetically predisposed individuals. Arising from consideration of the potential environmental triggers of PD, in vivo animal models of the disease utilizing these compounds are increasingly reported in the literature. Here, we review recent advances in the predominant models employing the insecticide Rotenone, the herbicide Paraquat and the fungicide Maneb, discuss their scientific merit and evaluate their relevance in the study of PD pathogenesis.

DOI: 10.1016/j.tips.2009.06.005
PubMed: 19729209

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a common neurodegenerative disorder largely of idiopathic nature with the exceptions of rare familial forms, and is characterized by both motor and non-motor disturbances. Pathologically, most motor features are the result of a dramatic loss of ventral tier mesencephalic dopaminergic neurons and thus dopamine content at their target sites. Although the exact etiology of the disease remains to be elucidated, it is thought to be multifactorial, with a critical role for environmental factors, such as pesticides, that may act on genetically predisposed individuals. Arising from consideration of the potential environmental triggers of PD, in vivo animal models of the disease utilizing these compounds are increasingly reported in the literature. Here, we review recent advances in the predominant models employing the insecticide Rotenone, the herbicide Paraquat and the fungicide Maneb, discuss their scientific merit and evaluate their relevance in the study of PD pathogenesis.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.